SSEA5 Mouse anti-Human, Clone: 8E11-SSEA5, eBioscience™ Invitrogen™
Mouse Monoclonal Antibody
The MAb 8E11-SSEA5 recognizes human stage-specific embryonic antigen-5 (SSEA-5), an H type-1 glycan. SSEA-5 belongs to the SSEA family of glycoproteins and is highly expressed on pluripotent human stem cells including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. During embryonic development, SSEA-5 is expressed within the blastocyst on inner cell mass (ICM) cells that later give rise to ES cells. As ES and iPS cells differentiate, SSEA-5 expression is downregulated. The tumorigenic potential of contaminating stem cells in cell populations for transplantation is a hurdle to using this approach for disease therapy. The 8E11 antibody in combination with either CD9 and CD90 or CD50 and CD200 to sort populations has been shown to effectively separate teratoma-forming cells from stem cell-derived populations of differentiated cells.SSEA5 Monoclonal antibody specifically detects SSEA5 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.09% sodium azide; pH 7.2|
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