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SSX4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550833

Catalog No. PA550833


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Description

Description

The antibody detects endogenous levels of total SSX4 protein.

SSX4 belongs to the SSX family. It contains 1 KRAB-related domain.SSX4 could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
Specifications

Specifications

SSX4
Polyclonal
Unconjugated
SSX4
Liquid
SSX4
Synthetic peptide corresponding to residues near the C terminal of human synovial sarcoma, X breakpoint 4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1.1 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
O60224
CT5.4
Rabbit
IgG
100 μL
-20°C
Primary
6759
Documents
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