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Invitrogen™ STAT Family Activation Human InstantOne™ ELISA Kit Non-distribution product as customer accommodation.

InstantOne ELISA

Manufacturer:  Invitrogen™ 858609511

Catalog No. 50-112-5029


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Includes: User Manual
InstantOne™ Assay Plate - 96 well (sealed)
Cell Lysis Buffer (5X)
Enhancer Solution
Wash Buffer (10X)
phospho-STAT1 (Tyr701) Capture Antibody Reagent
phospho-STAT3 (Tyr705) Capture Antibody Reagent
phospho-STAT5A/B (Tyr694/699) Capture Antibody Reagent
phospho-STAT1 (Tyr701) Detection Antibody Reagent
phospho-STAT3 (Tyr705) Detection Antibody Reagent
phospho-STAT5A/B (Tyr694/699) Detection Antibody Reagent
Positive Control Cell Lysate (lyophilized)
Detection Reagent (TMB Substrate)
Stop Solution
Plate Seal

Description

Description

The InstantOne™ ELISA is specifically engineered for accurate measurement of phosphorylated human STAT1 (Tyr701), STAT3 (Tyr705), and STAT5A/B (Tyr694/699) in cell lysates. Detection of mouse and rat phosphorylated STAT5A/B is also expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Specifications

Specifications

P40763,P42224,P42229,P51692
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Cell Lysate,20 μL
2-8°C
1 hr 10 min
STAT1, STAT3, STAT5A, STAT5B
HRP
Biotin
6772, 6774, 6776, 6777
Capture Antibody
96 tests
Cell Lysate
Human
1 hr 20 min
Human
Signal Transducer and Activator of Transcription
Documents
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