Invitrogen STAT Family Activation Human InstantOne ELISA Kit
Manufacturer: Invitrogen 858609511
The InstantOne ELISA is specifically engineered for accurate measurement of phosphorylated human STAT1 (Tyr701), STAT3 (Tyr705), and STAT5A/B (Tyr694/699) in cell lysates. Detection of mouse and rat phosphorylated STAT5A/B is also expected. The InstantOne ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
|Colorimetric Microplate Reader|
|Cell Lysate,20 μL|
|1 hr 10 min|
|STAT1, STAT3, STAT5A, STAT5B|
|6772, 6774, 6776, 6777|
|1 hr 20 min|
|Signal Transducer and Activator of Transcription|
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