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Stat1(pY701) Mouse, anti-Human, R718, Clone: 4A, BD Phosflow™

Mouse Monoclonal Antibody

$226.00 - $336.00


Antigen Stat1(pY701)
Applications Flow Cytometry
Clone 4A
Conjugate R718
Host Species Mouse
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Products 2
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Catalog Number Mfr. No. Quantity Price Quantity & Availability  
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BD Biosciences
100 Tests
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BD Biosciences
25 Tests
Each for $226.00
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Stat (Signal transducer and activators of transcription) proteins mediate the biological activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors. Ligand-receptor interaction activates constitutively-associated JAK family kinases as well as subsequent recruitment and activation of Stat proteins by tyrosine phosphorylation. Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes. Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, the primary transcription activator induced by interferon binding to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1α and 84-kDa Stat1β| Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex translocates to the nucleus. This forms an active complex that includes the DNA-binding p48 subunit, and is responsible for modulating interferon-stimulated genes (ISGs) transciption. The 4a monoclonal antibody recognizes the phosphorylated Y701 in Stat1α and Stat1β.



Refrigerate Upon Arrival
Flow Cytometry
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