Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7µM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
CAS Number: 40045-50-9
Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol
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