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Thermo Scientific Chemicals Sulindac Sulfide

Catalog Number aaj62104mc
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Quantity:
100 mg
32004-67-4
C20H17FO2S, C20H17FO2S
340.41
MFCD00869764
LFWHFZJPXXOYNR-RQZCQDPDSA-N
2-[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
CSC1=CC=C(\C=C2/C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1
32004-67-4
C20H17FO2S, C20H17FO2S
340.41
MFCD00869764
LFWHFZJPXXOYNR-RQZCQDPDSA-N
2-[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
CSC1=CC=C(\C=C2/C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1

Description

 

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY
Quantity 100 mg
Description Yellow
For Use With (Application) Active metabolite of sulindac; inhibits cyclooxygenase-1
Formula Weight 340.41g/mol
Melting Point 189°C to 191°C
Solubility Soluble in DMSO
Product Type Signal Transduction Reagent
Form Powder

Safety and Handling

EINECSNumber 250-892-2
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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