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Super-DHB suitable for matrix substance for MALDI-MS, ≥99% (HPLC), MilliporeSigma™ Supelco™
Supplier: MilliporeSigma Supelco 508625GF
Description
The “super-DHB” matrix consists of a 9:1 (w/w) mixture of 2,5-DHB and 2-hydroxy-5-methoxybenzoic acid, respectively, since this ratio was found to be the most effective. The beneficial effect of the 2-hydroxy- 5-methoxybenzoic acid additive is attributed to a disorder in the 2,5-DHB crystal lattice resulting in enhanced ion desorption (i.e. ‘softer’ desorption) and reduced internal energy, which in turn results in reduced metastable fragmentation. An increase in sensitivity of up to 2 to 3-fold has been reported for a standard dextran mixture with concomitant enhanced resolution attributed to reduced metastable ion formation. The super-DHB matrix has also been reported to generate enhanced signals from tryptic glycopeptides. The use of super-DHB matrix is reported to reduce the presence of matrix background ions and result in glycan signals exhibiting better signal to noise ratios and higher resolution in the mass spectrum.Specifications
| 63542-76-7 | |
| Organic Standard | |
| ≥99% (sum of DHB and 2-hydroxy-5-methoxybenzoi c acid, HPLC) |
| 5 g | |
| 9:1 mixture of DHB and 2-hydroxy-5-methoxybenzoic acid | |
| Soluble in methanol |
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