SUPV3L1 Mouse anti-Human, Clone: GT244, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527784
Positive Control: HeLa, H1299, HCT116, GFP-human SUV3-transfected HeLa cells Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.SUPV3L1 is a major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3 direction. SUPV3L1 plays a role in the RNA surveillance system in mitochondria regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. SUPV3L1 is also implicated in recombination and chromatin maintece pathways, may protect cells from apoptosis, and associates with mitochondrial DNA.
|PBS with no preservative|
|SUV3, SUPV3L1, SUV3-like protein 1, suppressor of var1, 3-like 1(SUV3), suppressor of var1 3-like protein 1, ATP-dependent RNA helicase SUPV3L1, mitochondrial, suppressor of var1, 3-like 1 (S. cerevisiae)|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunohistochemistry (Paraffin), Western Blot|
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