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Sur-8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 175611AP

Catalog No. 50-173-1646


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Description

Description

SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noo-like syndrome with loose anagen hair.
Specifications

Specifications

Sur-8
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O88520, Q6AYI5, Q9UQ13
KIAA0862, Protein soc 2 homolog, Protein sur 8 homolog, SHOC2, SIAA0862, SOC 2, SOC2, SUR 8, SUR8, sur-8
Rabbit
IgG
150 μL
-20°C
Primary
309548, 56392, 8036
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
SHOC2
Liquid
Shoc2
Sur-8 Fusion Protein Ag11754
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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