SUR1 Mouse anti-Hamster, Human, Mouse, Rat, Clone: S289-16, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527660
DescriptionThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal domit disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|AM60008PU-N, ABC36, Abcc8, ATP binding cassette sub family C member 8, HHF1, HRINS, MRP8, PHHI, SUR, SUR1, Sulfonylurea receptor (hyperinsulinemia), ATP binding cassette sub family C (CFTR/MRP) member 8, ATP binding cassette transporter sub family C member 8 (1), ATP-binding cassette sub-family C member 8, HI, PHHI, Sulfonylurea receptor 1, SUR1delta2, TNDM2|
|100764394, 20927, 25559, 6833|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot|
|Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1|
|Hamster, Human, Mouse, Rat|
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