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SUR1/SUR2B Mouse anti-Mouse, Rat, Clone: S323A-31, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527636

Catalog No. PIMA527636


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Description

Description

Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.
Specifications

Specifications

SUR1/SUR2B
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
P70170, Q09429, Q63563
ABC36, Abcc8, ABCC8_HUMAN, ATP binding cassette sub family C (CFTR/MRP) member 8, ATP binding cassette transporter sub family C member 8 (1), ATP-binding cassette sub-family C member 8, HHF1, HI, HRINS, MRP8, PHHI, Sulfonylurea receptor (hyperinsulinemia), Sulfonylurea receptor 1, SUR, SUR1, SUR1delta2, TNDM2, ABC37, abcC9, ABCC9_HUMAN, AI414027, AI449286, ATFB12, ATP-binding cassette sub-family C member 9, ATP-binding cassette transporter sub-family C member 9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9, CANTU, CMD1O, FLJ36852, Sulfonylurea receptor 2, Sulfonylurea-binding protein 2, SUR2, SUR2A, SUR2B
Mouse
IgG1
100 μg
-20°C
Primary
20928, 25560, 20927, 25559
Immunocytochemistry, Immunofluorescence, Western Blot
S323A-31
Unconjugated
Abcc9
Liquid
Abcc8, Abcc9
Fusion protein amino acids 1503-1545 (VHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRADM, cytoplasmic C-terminus) of rat SUR2B
Protein G
RUO
Antibody
Monoclonal
Mouse, Rat
Documents
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