Survivin Mouse anti-Human, PE, Clone: STLALYV, eBioscience™ Invitrogen™
Mouse Monoclonal Antibody
This STLALYV MAb recognizes human survivin (also known as Birc5). Survivin is a member of the inhibitor of apoptosis (IAP) family that also includes XIAP, c-IAP1, c-IAP2, and NAIP. Survivin functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Survivin also plays a critical role in mitosis and cytokinesis where it is expressed only during G2/M and localizes to the mitotic spindle and is found at the cleavage furrow/midplate. Thus, survivin is highly expressed in tumors and in fetal tissue, but is absent in terminally-differentiated cells and non-proliferating cells. Deletion of survivin in developing thymocytes as well as in mature T cells showed that survivin is critical for cell division in lymphoid cells but not for inhibition of survival; the same is true for B lymphocytes.Survivin Monoclonal antibody specifically detects Survivin in Human samples. It is validated for Flow Cytometry
|AAC-11; AP14; Api4; Apoptosis inhibitor 4; apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing 5 (survivin); Baculoviral IAP repeat-containing protein 5; BIRC 5; Birc5; EPR 1; EPR-1; IAP4; survivin; survivin variant 3 alpha; survivin40; SVV; TIAP|
|4° C, store in dark, DO NOT FREEZE!|
|PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2|
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