SWAP70 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA590085

Catalog No. PIPA590085

Description

Immunogen sequence: HKEARQRRKE LRKKQLAEQE ELERQMKELQ AANESKQQEL EAVRKKLEEA ASRAAEEEKK RLQTQVELQA RFSTELEREK LIRQQMEEQV AQKSSELEQY LQRVRELEDM YLKLQEALED ERQARQDEET VRKLQARLLE EESSKRAELE KWHLEQQQAI QTTEAEKQEL ENQRVLKEQA LQEAMEQLEQ LELERKQALE QYEEVKKKLE MATNKTKSWK DKVAHHEGLI RLIEPGSKNP HLITNWGPAA FTEAELEERE KNWKEKKTTE; Positive Samples: 293T, A549, LO2; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Nucleus, lamellipodium

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.

Specifications

• Antigen: SWAP70
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SWAP70
• Gene Symbols: Swap70
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 316-585 of human SWAP70
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 1.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6A028, Q9UH65
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20947, 23075
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid