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Syk Mouse anti-Human, PE, Clone: 4D10.1, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Catalog No. 12-669-642


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Description

Description

This 4D10.1 MAb recognizes human Syk, a 72-kDa member of the Syk/ZAP-70 family of non-receptor protein tyrosine kinases. Syk is expressed most highly in B cells, with lower expression in immature thymocytes, mast cells, and platelets. Syk can also be detected in fibroblasts, epithelial cells, hepatocytes, endothelial cells, and neuronal cells. This protein is a major component of signaling cascades downstream of the B and T cell antigen receptors and plays an essential role in lymphocyte development. Upon recruitment to immunoreceptor tyrosine-based activation motifs (ITAMs) on the antigen receptors, Syk is activated by phosphorylation on multiple tyrosines. Once activated, Syk phosphorylates proteins such as phospholipase C gamma and BLNK/SLP-65. Finally, abnormal Syk expression has been linked to tumor cell migration and invasion in several cancers.

Syk Monoclonal antibody specifically detects Syk in Human samples. It is validated for Flow Cytometry
Specifications

Specifications

Syk
Flow Cytometry
4D10.1
PE
Syk
DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; Syk; syk signaling; Sykb; tyrosine-kinase syk; Tyrosine-protein kinase SYK
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
6850
Liquid
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P43405
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
SDS
Documents
Product Certifications
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