TACC3 Mouse anti-Human, Clone: OTI3B1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525123
DescriptionTACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Transforming acidic coiled-coil-containing protein 3, ERIC-1, TACC3, ERIC1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TACC3 produced in HEK293T cell|
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