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Medchemexpress LLC Tafamidis meglumine | 951395-08-7 | MFCD28502032 | 99.8% | 503.33 | 1 ML
Supplier: Medchemexpress LLC HY14852A10MM/1ML
Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer. It shows comparable potency and efficacy to the mutant homotetramers V30M-TTR, V122I-TTR, and wild type WT-TTR, with EC50s of 2.7-3.2 μM. It inhibits amyloidogenesis. Tafamidis binds selectively and with negative cooperativity (Kds ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. It is for research use only and not sold to patients.
- Potent and selective transthyretin (TTR) stabilizer
- Inhibits amyloidogenesis
- Binds selectively to thyroxine-binding sites
- Kinetically stabilizes TTR
- Comparable potency to mutant and wild type TTR
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