Tocris™ TAK 960 hydrochloride

Potent and selective PLK1 inhibitor

Manufacturer: Tocris™ 5403/50

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Catalog No. 54-035-0

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For Research Use Only


    Specifications

    Description TAK 960 hydrochloride
    Molecular Weight 598.06
    Purity >98
    Quantity 50mg
    Product Type TAK 960 hydrochloride

    Potent PLK1 inhibitor (IC50 values are 0.8, 16.9 and 50.2nM for PLK1, PLK2 and PLK3 respectively). Exhibits >20-fold selectivity for PLK1 over FAK, MLCK and FES, and has minimal activity against a panel of 282 other kinases. Inhibits proliferation of a range of cancer cell lines in vitro and inhibits tumor growth of multiple human cancer cell xenografts in vivo. Orally bioavailable.

    • Chemical Name: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hydrochloride
    • Formula: C23H25F4N3O3S.HCl
    • CAS Number: 1137868-96-2
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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