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Tocris Bioscience™ TAK 960 hydrochloride

Potent and selective PLK1 inhibitor

Supplier:  Tocris Bioscience™ 5403/10

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Catalog No. 54-031-0


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Description

Description

TAK 960 hydrochloride is a potent PLK1 inhibitor (IC50 values are 0.8, 16.9 and 50.2 nM for PLK1, PLK2 and PLK3 respectively). Exhibits >20-fold selectivity for PLK1 over FAK, MLCK and FES, and has minimal activity against a panel of 282 other kinases. Inhibits proliferation of a range of cancer cell lines in vitro and inhibits tumor growth of multiple human cancer cell xenografts in vivo. Orally bioavailable.
Specifications

Specifications

>98%
TAK 960 hydrochloride
TAK 960 hydrochloride
2108449-45-0
598.06
10 mg
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