Invitrogen™ TANK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA525754

Catalog No. PIPA525754

Description

TANK Polyclonal Antibody for Western Blot, IHC (P), Flow

TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation of NF-kappa-B occurs through an association with the kinases IKK-iota and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Ikappa-B complex. This suggests that in addition to the possibility that TBK1 and IKK-iota activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.

Specifications

• Antigen: TANK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tank
• Gene Alias: C86182; E430026L09Rik; ITRAF; I-TRAF; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator; OTTHUMP00000200694; OTTHUMP00000200695; OTTHUMP00000200696; OTTHUMP00000200698; OTTHUMP00000200700; OTTHUMP00000200703; OTTHUMP00000200704; TANK; TANK-like protein; TRAF family member associated NFKB activator; TRAF family member-associated Nf-kappa B activator; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF interacting protein TANK; TRAF2; TRAF-interacting protein; zgc:153048
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10010
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q92844
• Gene Symbols: Tank
• Immunogen: KLH conjugated synthetic peptide between 88-114 amino acids from the central region of human TANK.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG