Invitrogen™ Tankyrase 2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518848

Catalog No. PIPA518848

Description

This antibody is predicted to react with canine and mouse based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt].

Specifications

• Antigen: Tankyrase 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNKS2
• Gene Alias: 5430432P15Rik; AA517131; ADP-ribosyltransferase diphtheria toxin-like 6; AI662480; ARTD6; PARP5B; PARP-5b; PARP5C; PARP-5c; pART6; Poly [ADP-ribose] polymerase 5B; Poly [ADP-ribose] polymerase tankyrase-2; Protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; tankyrase 2; tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-2; Tankyrase-like protein; tankyrase-related protein; TNKL; tnks 2; TNKS2; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 80351
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9H2K2
• Gene Symbols: TNKS2
• Immunogen: Synthetic peptide sequence (HRRKEVSEENHNH) corresponding to the internal amino acids of TNKS2 (aa 1011-1024).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG