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TBLR1 Mouse anti-Human, Mouse, Rat, Clone: OTI2A8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527517

Catalog No. PIMA527517


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Description

Description

Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid homone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
Specifications

Specifications

TBLR1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8BHJ5, Q9BZK7
C21, DC42, IRA1, TBLR1, F-box-like/WD repeat-containing protein TBL1XR1, TBL1-related protein 1, nuclear receptor co-repressor/HDAC3 complex subunit, nuclear receptor corepressor/HDAC3 complex subunit TBLR1, transducin beta-like 1X-related protein 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
365755, 79718, 81004
Western Blot
OTI2A8
Unconjugated
TBL1XR1
Liquid
Tbl1xr1
Full length human recombit protein of TBL1XR1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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