Dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28nM for TNKS1 and TNKS2 respectively, IC50 = 33nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19µM). Inhibits Wnt signaling and stabilizes Axin2 levels.
Chemical Name: 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole
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