Potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.
Chemical Name: 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
CAS Number: 1206170-62-8
Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol with gentle warming
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