Tocris™ TC-S 7006

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

Manufacturer: Tocris™ 5240/50

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Catalog No. 52-405-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type TC-S 7006
    Inhibitors TC-S 7006
    Purity >99
    Molecular Weight 404.83
    Quantity 50mg

    Potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.

    • Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
    • Formula: C21H14ClFN6
    • CAS Number: 871307-18-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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