Tocris TC-S 7006
Potent and selective Tpl2 (Cot; MAP3K8) inhibitor
Manufacturer: Tocris 5240/10
DescriptionPotent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.
- Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
- Formula: C21H14ClFN6
- CAS Number: 871307-18-5
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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