Tocris TC-S 7009
High affinity and selective HIF-2alpha inhibitor
Manufacturer: Tocris 5243/50
DescriptionHigh affinity and selective HIF-2α inhibitor (Kd = 81nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.
- Chemical Name: N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
- Formula: C12H6ClFN4O3
- CAS Number: 1422955-31-4
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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