Tocris™ TC-S 7009

High affinity and selective HIF-2alpha inhibitor

Manufacturer: Tocris™ 5243/10

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Catalog No. 52-431-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type TC-S 7009
    Inhibitors TC-S 7009
    Purity >99
    Molecular Weight 308.65
    Quantity 10mg

    High affinity and selective HIF-2α inhibitor (Kd = 81nM). Binds to the HIF-2α PAS-B domain; disrupts HIF-2α-ARNT heterodimerization. Exhibits >60-fold selectivity for HIF-2α over HIF-1α. Decreases HIF-2α DNA-binding and attenuates expression of HIF-2α target genes in vitro.

    • Chemical Name: N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
    • Formula: C12H6ClFN4O3
    • CAS Number: 1422955-31-4
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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