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TCCR Mouse anti-Human, Clone: 34N4G11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524795

Catalog No. PIMA524795


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Description

Description

IL-27R (WSX-1) is 65-70 kDa protein and is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes including CD4+ and CD8+ T cells, monocytes, DCs and NK cells

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
Specifications

Specifications

TCCR
Monoclonal
1 mg/mL
PBS with 0.05% sodium azide; pH 7.4
Q6UWB1
class I cytokine receptor, CRL1IL-27R, Cytokine receptor-like 1, IL27R, IL-27RA, IL-27R-alpha, interleukin 27 receptor, alpha, interleukin-27 receptor subunit alpha, TCCRIL-27 receptor subunit alpha, T-cell cytokine receptor type 1, Type I T-cell cytokine receptor, WSX-1, WSX1IL-27R subunit alpha, zcytor1
Mouse
IgG2b, kappa
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9466
Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin)
34N4G11
Unconjugated
IL27RA
Liquid
IL27RA
Amino acids 200-250 of human TCCR (WSX-1).
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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