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TCF2 Mouse anti-Human, Clone: CL0374, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524605

Catalog No. PIMA524605



Description

Description

Immunogen sequence: KEVLVQALEE LLPSPNFGVK LETLPLSPGS GAEPDTKPVF HTLTNGHAKG RLSGDEGSED GDDYDTPPIL KELQALNTEE AAEQRAEVDR MLSEDPWRAA KMIKGYMQQH Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%. Binds to an epitope located within the peptide sequence TPPILKELQA as determined by overlapping synthetic peptides.

Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

TCF2
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P35680
TCF2; VHNF1; transcription factor 2, hepatic LF-B3 variant hepatic nuclear factor; FJHN; HNF1B; HNF1beta; HNF2; LFB3; MODY5; transcription factor 2
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
6928
Immunohistochemistry, Western Blot
CL0374
Unconjugated
HNF1B
Liquid
HNF1B
Recombit protein corresponding to Human TCF2
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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