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TCF7 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Supplier: Active Motif 61580
SDSDocumentsProduct Certifications Promotions
DescriptionTCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
|AI465550; HMG-box; OTTHUMP00000159390; OTTHUMP00000159391; T cell factor-1; T-cell factor 1; T-cell specific; T-cell-specific transcription factor 1; Tcf1; Tcf-1; Tcf7; TCF-7; Transcription factor 7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7, T cell specific; transcription factor 7, T-cell specific|
|Antigen affinity chromatography|
|-20°C, Avoid Freeze/Thaw Cycles|
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|This antibody was raised against a peptide within the N-terminal region of human TCF7.|
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