Invitrogen™ TCP-1 zeta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528200

Catalog No. PIPA528200

Description

Recommended positive controls: A431, H1299, HeLa, HepG2, mouse brain. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (85%), Xenopus laevis (85%), Rabbit (96%), Chicken (89%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein TCP-1 (t complex polypeptide 1) is a subunit of the heterooligomeric complex CCT (chaperonin containing TCP-1) present in the eukaryotic cytosol. The CCT of eukaryotic cytosol is composed of eight different subunit species, TCP-1 alpha, beta, gamma, delta, epsilon, zeta, eta and theta, each encoded by a different gene. Two zeta subunits have been described: TCP-1 zeta (also designated TCP-1 zeta1) and TCP-1 zeta2. TCP-1 subunits are proposed to have independent functions in folding its in vivo substrates, the actins and tubulins. TCP-1 was first identified in the mouse as relevant for tail-less and embryonic lethal phenotypes. Sequences homologous to TCP-1 have been isolated in several other species, and the yeast TCP-1 has been shown to encode a molecular chaperone for Actin and Tubulin. TCP-1 found in mammalian cells and yeast plays an important role in the folding of cytosolic proteins.

Specifications

• Antigen: TCP-1 zeta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCT6A
• Gene Alias: acute morphine dependence related protein 2; acute morphine dependence-related protein 2; amino acid transport defect-complementing; CCT zeta1; CCT- zeta1; CCT- zeta-1; CCT zeta-1; Cct6; Cct6a; Cctz; Cctz1; Cctz-1; CCT-zeta; CCT-zeta-1; chaperonin containing T-complex subunit 6; chaperonin containing TCP-1; chaperonin containing TCP1 subunit 6A; chaperonin containing Tcp1, subunit 6A (zeta 1); chaperonin containing Tcp1, subunit 6a (zeta); chaperonin subunit 6a (zeta); histidine transp; histidine transport regulator 3; HTR3; MoDP-2; T-complex protein 1 subunit zeta; T-complex protein 1, zeta subunit; TCP 1 zeta; TCP1 zeta; TCP-1- zeta; TCP1- zeta; TCP-1-zeta; Tcp20; TCPZ; TTCP20
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12466, 908
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.53 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P40227, P80317
• Gene Symbols: CCT6A
• Immunogen: Recombinant fragment corresponding to a region within amino acids 117 and 417 of Human TCP1 zeta.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov