Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Piperidines
  7. TCS 46b, Tocris Bioscience™

TCS 46b, Tocris Bioscience™

Catalog Number 278250
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
302799-86-6
C22H23N3O
345.446
JJEXWPHPFZLTCU-UHFFFAOYSA-N
tcs 46b, 1,3-dihydro-5-3-4-phenylmethyl-1-2h-benzimidazol-2-one, 5-3-4-benzylpiperidino-1-propynyl-1h-benzimidazole-2 3h-one, 5-3-4-benzylpiperidin-1-yl prop-1-ynyl-1h-benzo d imidazol-2 3h-one, 5-3-4-benzyl-piperidin-1-yl-prop-1-ynyl-1,3-dihydro-benzoimidazol-2-one
9863010
5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one
C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4
This item is not returnable. View return policy
302799-86-6
C22H23N3O
345.446
JJEXWPHPFZLTCU-UHFFFAOYSA-N
tcs 46b, 1,3-dihydro-5-3-4-phenylmethyl-1-2h-benzimidazol-2-one, 5-3-4-benzylpiperidino-1-propynyl-1h-benzimidazole-2 3h-one, 5-3-4-benzylpiperidin-1-yl prop-1-ynyl-1h-benzo d imidazol-2 3h-one, 5-3-4-benzyl-piperidin-1-yl-prop-1-ynyl-1,3-dihydro-benzoimidazol-2-one
9863010
5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzimidazol-2-one
C1CN(CCC1CC2=CC=CC=C2)CC#CC3=CC4=C(C=C3)NC(=O)N4

Description

GluN1A/GluN2B-selective NMDA antagonist; orally bioavailable

Orally active, subtype-selective GluN1A/GluN2B (formally NR1A/NR2B) NMDA receptor antagonist (IC50 values are 5.3, 35000 and > 100000 nM for GluN1A/2B (NR1A/2B), GluN1A/2B (NR1A/2B) and GluN1A/2C (NR1A/2C) receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Quantity 50 mg
Formula Weight 345.44
Percent Purity >98%
Chemical Name or Material TCS 46b

Safety and Handling

Recommended Storage Store at Room Temperature
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit