Selective, ATP-competitive Pim kinase inhibitor (IC50 values are 24 and 100nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro (IC50 = 17µM).
Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
CAS Number: 438190-29-5
Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
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