TDG Mouse anti-Human, Clone: GT1142, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527785
Positive Control: human TDG -transfected 293T Predicted Reactivity: Mouse (100%), Rat (99%), Xenopus laevis (92%), Chicken (95%), Bovine (99%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.TDG encodes a protein that belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
|PBS with no preservative|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Recombit protein encompassing a sequence within the center region of human TDG. The exact sequence is proprietary.|
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