TDG / Thymine-DNA glycosylase Rabbit anti-Mouse, Unconjugated, Polyclonal, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Active Motif 61437
DescriptionThe protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
|TDG / Thymine-DNA glycosylase|
|-20°C, Avoid Freeze/Thaw Cycles|
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|C-JUN leucine zipper interactive protein JZA-3; E130317C12Rik; G/T mismatch-specific thymine DNA glycosylase; hTDG; Jza1; JZA-3; TDG; thymine DNA glycosylase; Thymine-DNA glycosylase|
|This antibody was raised against a full-length recombinant protein corresponding to mouse thymine DNA glycosylase (TDG).|
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