TDG Mouse anti-Human, Clone: OTI3A12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527004
DescriptionThe protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase; Short name=hTDG; Thymine DNA glycosylase; hTDG|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 160-253 of TDG produced in E.coli|
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