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TDO2 Mouse anti-Human, Clone: OTI2A4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526002

Catalog No. PIMA526002


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Description

Description

TDO2 (tryptophan 2,3-dioxygenase), also known as TO (tryptophan oxygenase) or TRPO (tryptophan pyrrolase), is a 406 amino acid protein that belongs to the tryptophan 2,3-dioxygenase family. Existing as a homotetramer, TDO2 binds two heme groups per tetramer. TDO2 has broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin, and it incorporates oxygen into the indole moiety of tryptophan. In doing so, TDO2 plays a major role in the tryptophan metabolism pathway. The gene that encodes TDO2 consists of approximately 65,669 bases and maps to hu-man chromosome 4q32.1. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington ft.s disease, is on located on chromosome 4. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia, polycystic kidney disease, thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer.
Specifications

Specifications

TDO2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P48775
Tryptophan 2,3-dioxygenase; TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase; TDO2; TDO
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6999
Immunohistochemistry (Paraffin), Western Blot
OTI2A4
Unconjugated
TDO2
Liquid
TDO2
Full length human recombit protein of TDO2 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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