TDP1 Mouse anti-Human, Clone: OTI4H1, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA503768
DescriptionThe protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|tyrosyl-DNA phosphodiesterase 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Full length human recombit protein of human TDP1 produced in HEK293T cell.|
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