The MAb 7UNA8U6 reacts with human, mouse, and rat TdT. TdT, or terminal-deoxynucleotidyl transferase, is a 60 kDa polymerase responsible for the template-independent addition of N-nucleotides at gene segment junctions of developing lymphocytes. Expression is found in the nucleus of immature lymphocytes but not in mature lymphocytes or non-lymphoid cells. TdT plays a critical role during TCR and Ig gene rearrangement and functions to increase the diversity of the lymphocyte repertoire through the addition of N-nucleotides onto the ends of newly formed P-nucleotides. After positive selection, expression of TdT becomes decreased or absent. Expression of TdT has been shown to be present in lymphoma or lymphoblastic leukemia cells.TdT Monoclonal antibody specifically detects TdT in Human, Mouse, Rat samples. It is validated for Immunohistochemistry (Paraffin), Western Blot
|PBS with 0.09% sodium azide; pH 7.2|
|deoxynucleotidyltransferase, terminal; DNA nucleotidylexotransferase; DNTT; nucleosidetriphosphate:DNA deoxynucleotidylexotransferase; Tdt; terminal addition enzyme; terminal deoxynucleotidyl transferase; terminal deoxynucleotidyltransferase; terminal deoxyribonucleotidyltransferase; terminal transferase|
|Immunohistochemistry (Paraffin), Western Blot|
|Human, Mouse, Rat|
|1791, 21673, 294051|
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