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TEF1 Mouse anti-Human, Clone: GT13112, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527786

Catalog No. PIMA527786


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Description

Description

Positive Control: HeLa NE Predicted Reactivity: Pig (100%), Chicken (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

TEF1 (Transcriptional enhancer factor 1), a member of the TEA/ATTS domain family, is a nuclear protein that is expressed in numerous cell types and plays a role in controlling the expression of numerous genes. TEF family members have a highly conserved DNA-binding domain TEF-1 binds to GT-IIC, SphI/II and M-CAT. TEF-1 also binds to the proximal regulatory element (PRE) of transforming growth factor-alpha, a member of the EGF family that is overexpressed in many types of cancer. Furthermore, TEF-1 represses transcription in placental cells. In vitro, TEF-1 is phosphorylated by several PKC isozymes. TEF-1 is phosphorylated in vivo at serine and threonine residues. Phosphorylation of TEF-1, both in vivo and in vitro, results in a reduction in its DNA-binding capability, which suggests a potential role for TEF-1 in PKC inhibition. TEF-1 also complexes with larger tumor antigen (TAg), and may thus have a role in tumorigenesis. Dimerization of TEF-1 may be important for TEF-1 to function as a regulator of gene transcription.
Specifications

Specifications

TEF1
Monoclonal
2.66 mg/mL
PBS with no preservative
P28347
TEF-1, TCF-13, NTEF-1, TEAD1, TEA domain family member 1 (SV40 transcriptional enhancer factor), TEAD-1, TCF13, AA, REF1
Mouse
IgG1
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
7003
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
GT13112
Unconjugated
TEAD1
Liquid
TEAD1
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human TEF1. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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