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CD248 Mouse anti-Human, Clone: OTI1H6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526838

Catalog No. PIMA526838


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Description

Description

Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion.
Specifications

Specifications

CD248
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9HCU0
CD164L1, MGC119478, MGC119479, TEM1, 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; endosialin; tumor endothelial marker 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
57124
Immunohistochemistry (Paraffin), Western Blot
OTI1H6
Unconjugated
CD248
Liquid
CD248
Human recombit protein fragment corresponding to amino acids 20-300 of CD248 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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