TERT Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA586083

Catalog No. PIPA586083

Description

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Specifications

• Antigen: TERT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TERT
• Gene Alias: CMM9, DKCA2, DKCB4, EST2, HEST2, hTERT, hTRT, PFBMFT1, RGD:70494}, TCS1, Telomerase catalytic subunit, telomerase reverse transcriptase, telomerase reverse transcriptase beta, telomerase-associated protein 2, TERT, tert {ECO:0000312, TP2, TR, TRT
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21752, 301965, 7015
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.2
• Gene Accession No.: O14746, O70372, Q673L6
• Gene Symbols: TERT
• Immunogen: Synthetic peptide, corresponding to amino acids 791-840 of Human TERT.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov