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Tet2 Mouse anti-Human, Clone: 21F11, Active Motif™

Mouse Monoclonal Antibody

Manufacturer:  Active MotifSupplier Diversity Partner 61389

Encompass

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Catalog No. 50-199-3365


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Description

Description

TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.
Specifications

Specifications

Tet2
Immunoprecipitation, Western Blot
1 mg/mL
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Q6N021
Ayu17-449; E130014J05Rik; FLJ20032; KIAA1546; MDS; Methylcytosine dioxygenase TET2; MGC125715; mKIAA1546; Nbla00191; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; RGD1311625; Tet 2; tet methylcytosine dioxygenase 2; tet oncogene 2; tet oncogene family member 2; Tet2
This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.
Protein A
RUO
Antibody
Monoclonal
Human
TET2
21F11
Unconjugated
TET2
Liquid
Mouse
IgG1, kappa
100 μg
-20°C, Avoid Freeze/Thaw Cycles
Primary
54790
SDS
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Product Certifications
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