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Tet2 Mouse anti-Human, Clone: 21F11, Active Motif™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$135.30 - $534.00

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen Tet2
Conjugate Unconjugated
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3366 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61390
10 μg
Each for $135.30
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50-199-3367 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61990
50 μg
Each for $308.55
Add to cart
 
50-199-3365 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61389
100 μg
Each for $534.00
Add to cart
 
Description

Description

TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.
Specifications

Specifications

Monoclonal
Primary
Tet2
Unconjugated
SDS
Product Certifications
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