Tocris™ Tetrabenazine

Potent inhibitor of vesicular monoamine transport

Manufacturer: Tocris™ 2175/50

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Catalog No. 21-755-0

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For Research Use Only


    Specifications

    Product Type Tetrabenazine
    Inhibitors Tetrabenazine
    Purity >98
    Molecular Weight 317.2
    Quantity 50mg

    Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC50= 3.2nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.

    • Chemical Name: (3R,11bR)-rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
    • Formula: C19H27NO3
    • CAS Number: 58-46-8
    • Solubility: Soluble to 30mM in ethanol and to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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