Tocris TFC 007
Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Manufacturer: Tocris 5108/10
DescriptionPotent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.
- Chemical Name: N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
- Formula: C27H29N5O4
- CAS Number: 927878-49-7
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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