High affinity and selective EP2 receptor antagonist (KB values are 2.4 and 34.5nM for EP2 and DP1 receptors respectively). Exhibits >500-fold selectivity for EP2 over other prostanoid receptors. Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.
Chemical Name: (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
CAS Number: 1164462-05-8
Solubility: Soluble to 100mM in DMSO and to 20mM in ethanol
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