Invitrogen™ TGIF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566463

Catalog No. PIPA566463

Description

Immunogen sequence: SVLARPSVICH TTVTALKDVP FSLCQSVGVG QNTDIQQIAA KNFTDTSLMY PEDTCKSGPS TNTQ Highest antigen sequence identity to the following orthologs - mouse 82%, rat 77%.

TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.

Specifications

• Antigen: TGIF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TGIF1
• Gene Alias: 5'-TG-3'-interacting factor 1; AA959811; AI462167; Homeobox protein TGIF1; HPE4; TALE family homeobox; TALE homeobox TG-interacting factor; Tfig; TG interacting factor 1; TGFB induced factor homeobox 1; TGFB-induced factor homeobox 1; TGIF; Tgif1; transforming growth factor-beta-induced factor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7050
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15583
• Gene Symbols: TGIF1
• Immunogen: Recombinant Human TGIF. Recombinant protein control fragment (Product #RP-105224).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG