TGIF Mouse anti-Human, Clone: OTI1A6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526539
DescriptionTGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Homeobox protein TGIF1, 5′-TG-3′-interacting factor 1, TGIF1, TGIF|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TGIF1 produced in E.coli|
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