Thermo Scientific™ Lab Vision™ Insulin Receptor (α -Subunit) Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ MS631P1

Catalog No. MS631P1

Description

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a Β-α-α-Β configuration. The Β-subunit (95kDa) possesses a single transmembrane domain, whereas the α-subunit (135kDa) is completely extracellular.

Host Species: Mouse

Clone: 83-14

Isotype: IgG2a/κ

Species Reactivity: Human. Weakly with Cow, Pig and Sheep. Does not react with rabbit, mouse and rat. Others not known.

Epitope: aa 469-592 (exon 7/8)

Immunogen: IM-9 lymphocytes followed by purified insulin receptor

Molecular Weight: 135kDa

Positive Control: IM-9 lymphocyte cells, Placenta

Cellular Localization: Membrane Ab-1 inhibits insulin binding and mimics insulin action. It is excellent for immunoprecipitation of alpha-subunit of IR.

Recommended for:

• Immunoprecipitation
• ELISA
• Insulin-like Agonist
• Inhibits (~80%) Insulin Binding (10nM)
• Tyrosine Kinase Assay (Ab-mediated capture on microplates)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Insulin Receptor (alpha-Subunit) Ab-1
• Classification: Monoclonal
• Concentration: 200μg/mL
• Format: Concentrated
• Immunogen: IM-9 lymphocytes followed by purified insulin receptor
• Quantity: 500μL
• Research Discipline: Steroids Hormones and Growth Factors
• Primary or Secondary: Primary
• Target Species: Human

• Applications: Immunoprecipitation
• Clone: 83-14
• Conjugate: Unconjugated
• Host Species: Murine
• Isotype: IgG2a kappa
• Regulatory Status: RUO
• Type: Primary
• Monoclonal or Polyclonal: Monoclonal